Declomycin

DRUG DESCRIPTION

DECLOMYCIN demeclocycline hydrochloride is an antibiotic isolated from a mutant
strain of Streotomyces aureofaciens. Chemically it is7-Chloro-4.(dimethylamino)-1,4,4a,5,5a,6.11,12a-octahydro-3,6,10.12.12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamidemonohydrochloride.

Its structural formula is:

DECLOMYCIN (demeclocycline hcl) Tablets for oral administration contain 150 mg or 300 mg of demeclocycline
hydrochloride and the following inactive ingredients: Alginic Acid, Corn Starch,
Ethylcellulose, Hypromellose, Magnesium Stearate, D&C Red 7, Sorbitol, Titanium
Dioxide, FD&C Yellow 10 and other ingredients. May also contain Sodium Lauryl
Sulfate.

What are the possible side effects of demeclocycline (Declomycin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using demeclocycline and call your doctor at once if you have any of these serious side effects:

• severe headache, dizziness, blurred vision;


• fever, chills, body aches, flu symptoms;


• severe blistering, peeling, and red skin rash;


• urinating less than usual or not at all;


• pale or yellowed skin, dark colored urine,...

Read All Potential Side Effects and See Pictures of Declomycin »

What are the precautions when taking demeclocycline hcl (Declomycin)?

Before taking demeclocycline, tell your doctor or pharmacist if you are allergic to it; or to other tetracycline medication (e.g., doxycycline, minocycline, tetracycline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, problems swallowing, esophagus problems (e.g., esophageal ulcers, hiatal hernia, acid reflux disease-GERD), lupus, a certain hormone imbalance called "water diabetes" (diabetes insipidus).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you...

Read All Potential Precautions of Declomycin »

Declomycin Consumer (continued)

SIDE EFFECTS: Diarrhea, loss of appetite, nausea, vomiting, headache, dizziness, lightheadedness, or rectal discomfort may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: sunburn-like skin reaction (sun sensitivity), darkening of the skin and other areas of the body (e.g., lips, inside of the mouth), difficult/painful swallowing, unusual increase in the amount of urine (except for the expected increase in urination if you are treating SIADH), unusual decrease in the amount of urine or no urine, unusual thirst, weakness, unusual tiredness, brown/gray tooth discoloration.

Tell your doctor immediately if any of these rare but very serious side effects occur: hearing changes (e.g., ringing in the ears, decreased hearing), persistent/severe headache, vision changes (e.g., blurred vision), easy bruising/bleeding, new signs of infection (e.g., persistent sore throat, fever, chills), stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction, including: rash, skin sores/blisters, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, new or worsening swelling/pain in the joints, chest pain, fast/irregular heartbeat.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking demeclocycline, tell your doctor or pharmacist if you are allergic to it; or to other tetracycline medication (e.g., doxycycline, minocycline, tetracycline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, problems swallowing, esophagus problems (e.g., esophageal ulcers, hiatal hernia, acid reflux disease-GERD), lupus, a certain hormone imbalance called "water diabetes" (diabetes insipidus).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Before having surgery, tell your doctor or dentist that you are using demeclocycline.

This medication should not be used in children younger than 8 years of age because it may cause permanent tooth discoloration and other problems. Tooth discoloration has also occurred in older children and young adults. Consult your doctor for more information.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details and to discuss reliable forms of birth control.

This medication passes into breast milk in very small amounts. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Declomycin Patient Information Including Side Effects

Brand Names: Declomycin

Generic Name: demeclocycline (Pronunciation: DEM e kloe SYE kleen)

• What is demeclocycline (Declomycin)?


• What are the possible side effects of demeclocycline (Declomycin)?


• What is the most important information I should know about demeclocycline (Declomycin)?


• What should I discuss with my healthcare provider before taking demeclocycline (Declomycin)?


• How should I take demeclocycline (Declomycin)?


• What happens if I miss a dose (Declomycin)?


• What happens if I overdose (Declomycin)?


• What should I avoid while taking demeclocycline (Declomycin)?


• What other drugs will affect demeclocycline (Declomycin)?


• Where can I get more information?

What is demeclocycline (Declomycin)?

Demeclocycline is a tetracycline antibiotic. It fights bacteria in the body.

Demeclocycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, and others.

Demeclocycline may also be used for other purposes not listed in this medication guide.

What are the possible side effects of demeclocycline (Declomycin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using demeclocycline and call your doctor at once if you have any of these serious side effects:

• severe headache, dizziness, blurred vision;


• fever, chills, body aches, flu symptoms;


• severe blistering, peeling, and red skin rash;


• urinating less than usual or not at all;


• pale or yellowed skin, dark colored urine, fever, confusion or weakness;


• severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;


• loss of appetite, jaundice (yellowing of the skin or eyes); or


• easy bruising or bleeding, unusual weakness.

Less serious side effects may include:

• sores or swelling in your rectal or genital area;


• mild nausea, vomiting, diarrhea, or stomach upset;


• white patches or sores inside your mouth or on your lips;


• swollen tongue, trouble swallowing; or


• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about demeclocycline (Declomycin)?

Do not use this medication if you are pregnant. It could cause harm to the unborn baby, including permanent discoloration of the teeth later in life. Demeclocycline can make birth control pills less effective. Use a second method of birth control while you are taking demeclocycline to keep from getting pregnant.

Demeclocycline passes into breast milk and may affect bone and tooth development in a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby.

Do not give demeclocycline to a child younger than 8 years old. Demeclocycline can cause permanent yellowing or graying of the teeth, and it can affect a child's growth.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Demeclocycline can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking demeclocycline. These products can make demeclocycline less effective.

Throw away any unused demeclocycline when it expires or when it is no longer needed. Do not take any demeclocycline after the expiration date on the label has passed. Expired demeclocycline can cause a dangerous syndrome resulting in damage to the kidneys.

Related Drug Centers

• Declomycin